2-chloro-3-cyclohexylideneacetyl chloride

Base Information

• Chemical Name: 2-chloro-3-cyclohexylideneacetyl chloride
• CAS No.: 83323-25-5
• Molecular Formula: C₈H₁₀Cl₂O
• Molecular Weight: 193.073
• Mol file: 83323-25-5.mol

Synonyms:2-chloro-3-cyclohexylideneacetyl chloride

Chemical Property of 2-chloro-3-cyclohexylideneacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-chloro-3-cyclohexylideneacetyl chloride

There total 3 articles about 2-chloro-3-cyclohexylideneacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-2-cyclohexylideneacetic acid (58229-17-7) → 2-chloro-3-cyclohexylideneacetyl chloride (83323-25-5)

Guidance literature:

In thionyl chloride; for 4h; Heating;

DOI:10.1002/hlca.19820650203

Reference yield:

ethyl (2-chlorocyclohexylidene)acetate (66051-41-0) → 2-chloro-3-cyclohexylideneacetyl chloride (83323-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N KOH / dioxane; H₂O / 15 h / Heating

2: 90 percent / SOCl₂ / 4 h / Heating

With potassium hydroxide; In 1,4-dioxane; thionyl chloride; water;

DOI:10.1002/hlca.19820650203

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-chloro-3-cyclohexylideneacetyl chloride (83323-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Na (55-60percent disp. in mineral oil) / 1.) DME, 0 deg C, then Rt, 30 min; 2.) DME, reflux, 4 h

2: 2N KOH / dioxane; H₂O / 15 h / Heating

3: 90 percent / SOCl₂ / 4 h / Heating

With potassium hydroxide; sodium; In 1,4-dioxane; thionyl chloride; water;

DOI:10.1002/hlca.19820650203

upstream raw materials:

2-chloro-2-cyclohexylideneacetic acid

ethyl (2-chlorocyclohexylidene)acetate

cyclohexanone