(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

Base Information

Chemical Name:(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]
CAS No.:1314789-52-0
Molecular Formula:C₂₂H₂₄F₂N₄O₆S₂
Molecular Weight:542.585
Hs Code.:

Synonyms:(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

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Technology Process of (2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

There total 3 articles about (2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 51-85-4
2,2'-dithio-bis[ethylamine]

: 1314789-45-1
(E)-3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid

: 1314789-52-0
(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

Guidance literature:: (E)-3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid; With N-hydroxyphthalimide; dicyclohexyl-carbodiimide; In 1,4-dioxane; at 25 ℃; for 2h; Inert atmosphere;

2,2'-dithio-bis[ethylamine]; With triethylamine; In 1,4-dioxane; methanol; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.12.026

Reference yield:

: m-fluoro-DL-tyrosine methyl ester

: 1314789-52-0
(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / ethanol; water / 3 h / 25 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 23 °C / Inert atmosphere

3.1: N-hydroxyphthalimide; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

With N-hydroxyphthalimide; sodium tungstate (VI) dihydrate; dihydrogen peroxide; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2010.12.026

Reference yield:

: 1314789-32-6
(E)-methyl 3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanoate

: 1314789-52-0
(2E,2'E)-N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-fluoro-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 23 °C / Inert atmosphere

2.1: N-hydroxyphthalimide; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

With N-hydroxyphthalimide; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmc.2010.12.026