(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Base Information

Chemical Name:(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid
CAS No.:112917-81-4
Molecular Formula:C₂₂H₃₁NO₄S
Molecular Weight:405.558
Hs Code.:

Synonyms:(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Suppliers and Price of (+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

There total 8 articles about (+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

: 112917-80-3
methyl (+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoate

: 112917-81-4
(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 2h; Ambient temperature;
DOI:10.1248/cpb.37.1524

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 112917-81-4
(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 60percent sodium hydride / 1.) DMSO, room temperature, 2.) ether, 10 min,

2: 96.6 percent / K₂Cr₂O₇, H₂SO₄ / acetone / 1 h / 0 °C

3: 1.) ethyl chloroformate, 2.) sodium azide / 1.) acetone, 0 deg C, 1 h, 2.) acetone, water, 0 deg C, 1 h,

4: benzene / 0.5 h / Heating

5: 72 h / Heating

6: 1.) trifluoroacetic acid, 2.) triethylamine / 1.) room temperature, 30 min, 2.) CH₂Cl₂, room temperature, 20 min,

7: 95.3 percent / 10percent aqeous sodium hydroxide / methanol / 2 h / Ambient temperature

With potassium dichromate; sodium hydroxide; sodium azide; sulfuric acid; chloroformic acid ethyl ester; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; acetone; benzene;
DOI:10.1248/cpb.37.1524

Reference yield:

: 86778-00-9,86833-03-6,86833-04-7,86833-05-8,86833-06-9
(-)-(4aR,6S,8S,8aS)-7,7-Dimethyl-6,8-methano-perhydroisochroman-3-ol

: 112917-81-4
(+)-(5Z)-7-((1R,2S,3S,5S)-2-benzenesulfonylamino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 60percent sodium hydride / 1.) DMSO, room temperature, 2.) ether, 10 min,

2: 96.6 percent / K₂Cr₂O₇, H₂SO₄ / acetone / 1 h / 0 °C

3: 1.) ethyl chloroformate, 2.) sodium azide / 1.) acetone, 0 deg C, 1 h, 2.) acetone, water, 0 deg C, 1 h,

4: benzene / 0.5 h / Heating

5: 72 h / Heating

6: 1.) trifluoroacetic acid, 2.) triethylamine / 1.) room temperature, 30 min, 2.) CH₂Cl₂, room temperature, 20 min,

7: 95.3 percent / 10percent aqeous sodium hydroxide / methanol / 2 h / Ambient temperature

With potassium dichromate; sodium hydroxide; sodium azide; sulfuric acid; chloroformic acid ethyl ester; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; acetone; benzene;
DOI:10.1248/cpb.37.1524