[N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester

Base Information

• Chemical Name: [N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester
• CAS No.: 871590-47-5
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.411
• Mol file: 871590-47-5.mol

Synonyms:[N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester

Chemical Property of [N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester

There total 1 articles about [N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[N'-tert-butoxycarbonyl-N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester → [N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester (871590-47-5)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1055/s-2005-917100

Reference yield: 55.0%

[N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester (871590-47-5) + N'-isobutyl-N'-(2-oxo-ethyl)-hydrazinecarboxylic acid 9H-fluoren-9-ylmethyl ester (871590-45-3) → Fmoc-aza-β3-Leu-ψ(CH=N)-aza-β3-Tyr(OCH2OEt)-OBn

Guidance literature:

With sodium sulfate; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1055/s-2005-917100

Reference yield:

[N-(4-ethoxymethoxy-benzyl)-hydrazino]-acetic acid benzyl ester (871590-47-5) → Fmoc-aza-β3-Leu-ψ(CH2NBoc)-aza-β3-Tyr(OCH2OEt)-OH

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / Na₂SO₄ / CH₂Cl₂ / 12 h / 20 °C

2: 72 percent / NaBH₃CN; aq. HCl / methanol / 2 h / pH 3

3: 41 percent / DIPEA / dioxane / 24 h / 50 °C

4: 75 percent / H₂ / Pd/C / methanol / 0.5 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; sodium sulfate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1055/s-2005-917100

Downstream raw materials:

Fmoc-aza-β³-Leu-ψ(CH2NH)-aza-β³-Ala-OBn

Fmoc-aza-β³-Leu-ψ(CH2NBoc)-aza-β³-Ala-OBn

Fmoc-aza-β³-Leu-ψ(CH2NH)-aza-β³-Tyr(OCH2OEt)-OBn

Fmoc-aza-β³-Leu-ψ(CH2NBoc)-aza-β³-Tyr(OCH2OEt)-OBn