Phenpromethamine, (R)-

Base Information

• Chemical Name: Phenpromethamine, (R)-
• CAS No.: 26191-38-8
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.236
• UNII: HYN9J5PM3D
• Nikkaji Number: J76.798K
• Mol file: 26191-38-8.mol

Synonyms:Phenpromethamine, (R)-;HYN9J5PM3D;SCHEMBL4917327;N-Methyl((R)-2-phenylpropyl)amine;AKOS006357865;(betaR)-N,beta-Dimethylbenzeneethanamine;Benzeneethanamine, N,beta-dimethyl-, (R)-;Benzeneethanamine, N,beta-dimethyl-, (betaR)-;Phenethylamine, N,beta-dimethyl-, (R)-(+)-;26191-38-8

Chemical Property of Phenpromethamine, (R)-

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 95

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CNC)C1=CC=CC=C1
• Isomeric SMILES: C[C@@H](CNC)C1=CC=CC=C1

Technology Process of Phenpromethamine, (R)-

There total 9 articles about Phenpromethamine, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(R)-2-[Methyl-(2-phenyl-propyl)-amino]-2-phenyl-ethanol → [R]-(+)-N-methyl-2-phenylpropylamine (26191-38-8)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; under 750.06 Torr;

DOI:10.1055/s-1997-1303

Reference yield: 34.0%

(R)-N-methyl-2-phenylpropionamide (270258-71-4) → [R]-(+)-N-methyl-2-phenylpropylamine (26191-38-8)

Guidance literature:

With 1,1,3,3-Tetramethyldisiloxane; (μ₃,η²,η³,η⁵-acenaphthylene)Ru(CO)7; In 1,2-dimethoxyethane; at 60 ℃; for 12h;

DOI:10.1021/jo070591c

Reference yield:

(R)-2-Phenylpropionic acid (7782-26-5) → [R]-(+)-N-methyl-2-phenylpropylamine (26191-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / benzene

2: triethylamine / diethyl ether

3: 34 percent / 1,1,3,3-tetramethyldisiloxane / (μ₃,η²,η³,η⁵-acenaphthylene)Ru(CO)7 / 1,2-dimethoxy-ethane / 12 h / 60 °C

With thionyl chloride; 1,1,3,3-Tetramethyldisiloxane; triethylamine; (μ₃,η²,η³,η⁵-acenaphthylene)Ru(CO)7; In 1,2-dimethoxyethane; diethyl ether; benzene;

DOI:10.1021/jo070591c

upstream raw materials:

phenpromethamine

(R)-N-methyl-2-phenylpropionamide

(R)-2-Phenylpropionic acid

(R)-(-)-2-phenylpropionyl chloride