(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

Base Information

Chemical Name:(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane
CAS No.:122629-74-7
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

Chemical Property:

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Technology Process of (1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

There total 5 articles about (1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 122629-73-6
(1R,2R)-2-benzyloxymethyl-2-ethoxycarbonyl-1-(tetrahydropyran-2-yl)oxycyclopentane

: 122629-74-7
(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1248/cpb.36.4337

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 122629-74-7
(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / p-TsOH / CH₂Cl₂ / 3 h

2: 84 percent / LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane;
DOI:10.1248/cpb.36.4337

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 122629-74-7
(1R,2R)-2-benzyloxymethyl-2-hydroxymethyl-1-(tetrahydropyran-2-yl)oxycyclopentane

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent Spectr_. / LDA / hexane; tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C

2: 84 percent / p-TsOH / CH₂Cl₂ / 3 h

3: 84 percent / LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane;
DOI:10.1248/cpb.36.4337