1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

Chemical Name:1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS No.:1431840-05-9
Molecular Formula:C₄₀H₅₉N₂O₆PSi
Molecular Weight:722.978
Hs Code.:

Synonyms:1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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Chemical Property of 1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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Technology Process of 1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 3 articles about 1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1431840-07-1
1-(tert.-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxy-2(R)-butanol

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1431840-05-9
1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: With N,N-dimethyl-ethanamine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1002/anie.201208103

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1431840-05-9
1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 6 h / 20 °C / Inert atmosphere

2: 1,4-bis(9-O-dihydroquinidine)phthalazine / tert-butyl alcohol; water / 24 h / 0 °C

3: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

4: N,N-dimethyl-ethanamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; N,N-dimethyl-ethanamine; 1,4-bis(9-O-dihydroquinidine)phthalazine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201208103

Reference yield:

: 166887-39-4
4-(4,4’-dimethoxytrityl)oxy-1-butene

: 1431840-05-9
1-(tert-butyldimethylsilyl)oxy-4-(4,4’-dimethoxytrityl)oxybutane-2(R)-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-bis(9-O-dihydroquinidine)phthalazine / tert-butyl alcohol; water / 24 h / 0 °C

2: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

3: N,N-dimethyl-ethanamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With 1H-imidazole; N,N-dimethyl-ethanamine; 1,4-bis(9-O-dihydroquinidine)phthalazine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201208103