5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole
CAS No.:852245-03-5
Molecular Formula:C₂₁H₃₆N₄O₅SSi
Molecular Weight:484.692
Hs Code.:

5-[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1<i>H</i>-tetrazole

Synonyms:5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 8 articles about 5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852245-21-7
(S)-5-Benzyloxy-2-methyl-pentane-1,2-diol

: 852245-03-5
5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; DMAP / CH₂Cl₂ / 72 h / 20 °C

2: (i-Pr)2NEt / CH₂Cl₂ / 72 h / 20 °C

3: 12.45 g / H₂ / Pd/C / ethanol / 48 h

4: 80 percent / Ph₃P; DIAD / tetrahydrofuran / 20 °C

5: mCPBA; NaHCO₃ / CH₂Cl₂ / 17 h

With dmap; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 4: Mitsunobu reaction;
DOI:10.1021/ol0504291

Reference yield:

: 852245-00-2
5-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pentan-2-ol

: 852245-03-5
5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: (i-Pr)2NEt / CH₂Cl₂ / 72 h / 20 °C

2: 12.45 g / H₂ / Pd/C / ethanol / 48 h

3: 80 percent / Ph₃P; DIAD / tetrahydrofuran / 20 °C

4: mCPBA; NaHCO₃ / CH₂Cl₂ / 17 h

With di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/ol0504291

Reference yield:

: 852245-01-3
(5-benzyloxy-2-methoxymethoxy-2-methyl-pentyloxy)-tert-butyl-dimethyl-silane

: 852245-03-5
5-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxymethoxy-4-methyl-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 12.45 g / H₂ / Pd/C / ethanol / 48 h

2: 80 percent / Ph₃P; DIAD / tetrahydrofuran / 20 °C

3: mCPBA; NaHCO₃ / CH₂Cl₂ / 17 h

With di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/ol0504291