Technology Process of buprenorphine PABA carbamate hydrochloride
There total 5 articles about buprenorphine PABA carbamate hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / dichloromethane; toluene; water / 0.25 h / 0 - 20 °C
2: toluene / Reflux
3: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4: hydrogenchloride / diethyl ether
With
hydrogenchloride; hydrogen; sodium hydrogencarbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate; toluene;
1: Schotten-Baumann Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / dichloromethane; toluene / 2 h / 0 - 20 °C / Inert atmosphere
2: toluene / Reflux
3: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4: hydrogenchloride / diethyl ether
With
pyridine; hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
1: Schotten-Baumann Reaction;
