(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

Base Information

Chemical Name:(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane
CAS No.:78462-64-3
Molecular Formula:C₂₇H₂₈O₅
Molecular Weight:432.516
Hs Code.:

Synonyms:(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

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Chemical Property of (1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

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Technology Process of (1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

There total 7 articles about (1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 78462-63-2
Toluene-4-sulfonic acid (2R,3R,4S,5S,6S)-3-hydroxy-5,6-dimethoxy-2-trityloxymethyl-tetrahydro-pyran-4-yl ester

: 78462-64-3
(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ja00323a032

Reference yield:

: 617-04-9
(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol

: 78462-64-3
(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 6 steps

1: 47.1 percent / pyridinium p-toluenesulfonate / acetone; dimethylformamide / 36 h / 5 °C

2: 53.2 g / CH₂Cl₂; pyridine / 60 h

3: 60 percent / NaH / tetrahydrofuran / 1.5 h / Ambient temperature

4: 100 percent / Dowex 50W (H+) / methanol / 3.5 h / Ambient temperature

5: 86 percent / pyridine / 1.5 h / 70 °C

6: 86 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C

With Dowex 50W (H+); potassium tert-butylate; sodium hydride; pyridinium p-toluenesulfonate; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja00323a032

Reference yield:

: 63167-67-9
methyl 4,6-O-isopropylidene-α-D-mannopyranoside

: 78462-64-3
(1R,2R,4S,5S,6R)-4,5-Dimethoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 5 steps

1: 53.2 g / CH₂Cl₂; pyridine / 60 h

2: 60 percent / NaH / tetrahydrofuran / 1.5 h / Ambient temperature

3: 100 percent / Dowex 50W (H+) / methanol / 3.5 h / Ambient temperature

4: 86 percent / pyridine / 1.5 h / 70 °C

5: 86 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C

With Dowex 50W (H+); potassium tert-butylate; sodium hydride; In tetrahydrofuran; pyridine; methanol; dichloromethane;
DOI:10.1021/ja00323a032