2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Base Information

Chemical Name:2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile
CAS No.:1607429-03-7
Molecular Formula:C₂₂H₂₁FN₆O₃
Molecular Weight:436.446
Hs Code.:

Synonyms:2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Suppliers and Price of 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

There total 19 articles about 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293284-51-1
3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

: 1607429-29-7
3-methoxy-2-{[(3R,6R)-6-methylpiperidin-3-yl]oxy}pyridin-4-carbonitrile hydrochloride

: 1607429-03-7
2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: (±)-benzyl trans-5-hydroxy-2-methylpiperidine-1-carboxylate

: 1607429-03-7
2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / 0.17 h / -78 °C

1.2: 0.25 h / -78 °C

2.1: lithium borohydride; methanol / tetrahydrofuran / -10 - 20 °C

3.1: carbon dioxide / methanol

4.1: diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / -25 - 20 °C / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran; methanol

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

7.1: sodium hydride / dimethyl sulfoxide / 0.25 h

7.2: 40 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 130 °C / Inert atmosphere; Sealed tube

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / -78 - 20 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; methanol; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; carbon dioxide; palladium 10% on activated carbon; water; hydrogen; sodium hydride; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Swern Oxidation;

Reference yield:

: 1314395-91-9
(±)-benzyl 2-methyl-5-oxopiperidine-1-carboxylate

: 1607429-03-7
2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methoxypyridin-4-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium borohydride; methanol / tetrahydrofuran / -10 - 20 °C

2.1: carbon dioxide / methanol

3.1: diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / -25 - 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran; methanol

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

6.1: sodium hydride / dimethyl sulfoxide / 0.25 h

6.2: 40 °C

7.1: hydrogenchloride / 1,4-dioxane; dichloromethane / -78 - 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; methanol; lithium borohydride; 1-hydroxy-7-aza-benzotriazole; carbon dioxide; palladium 10% on activated carbon; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;