2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

Base Information

Chemical Name:2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid
CAS No.:952661-18-6
Molecular Formula:C₃₉H₄₀NO₇P
Molecular Weight:665.723
Hs Code.:

Synonyms:2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

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Chemical Property of 2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

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Technology Process of 2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

There total 7 articles about 2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₀NPO₆C₂H₄(C₈H₆O)2

: 952661-18-6
2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jo071081l

Reference yield:

: 865703-11-3
2-benzyl-3-hydroxyphosphinoyl-propionic acid

: 952661-18-6
2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 447 mg / AcCl / 5 h / 20 °C

2: Et₃N / ethyl acetate / 24 h / 20 °C

3: 262 mg / TFA / CH₂Cl₂ / 20 °C

With triethylamine; acetyl chloride; trifluoroacetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jo071081l

Reference yield:

: C₁₂H₁₄O₂HPO₂(SiC₃H₉)2

: 952661-18-6
2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH; MeOH

2: 447 mg / AcCl / 5 h / 20 °C

3: Et₃N / ethyl acetate / 24 h / 20 °C

4: 262 mg / TFA / CH₂Cl₂ / 20 °C

With methanol; sodium hydroxide; triethylamine; acetyl chloride; trifluoroacetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jo071081l