{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Base Information

Chemical Name:{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride
CAS No.:86260-70-0
Molecular Formula:C₂₉H₂₆F₃N₇O₂*2ClH
Molecular Weight:634.488
Hs Code.:

{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Synonyms:{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

There total 4 articles about {2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 86272-02-8
<<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone

: 51388-03-5
5-amino-N-ethyl-2-methoxybenzenemethanamine dihydrochloride

: 86260-70-0
{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 3h;
DOI:10.1021/jm00363a017

Reference yield:

: 57070-71-0
(3,4-diaminophenyl)phenylmethanone hydrochloride

: 86260-70-0
{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 2-ethoxy-ethanol / 24 h / Heating

2: POCl₃ / 1.5 h / 100 °C

3: 26 percent / dimethylformamide / 3 h / 110 °C

With trichlorophosphate; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00363a017

Reference yield:

: 86260-51-7
[2-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-ylamino)-1H-benzoimidazol-5-yl]-phenyl-methanone

: 86260-70-0
{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / 1.5 h / 100 °C

2: 26 percent / dimethylformamide / 3 h / 110 °C

With trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00363a017