3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

Base Information

• Chemical Name: 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester
• CAS No.: 1283087-62-6
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37

Synonyms:3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

Chemical Property of 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

Chemical Property:

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Technology Process of 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

There total 2 articles about 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester (1283087-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine N-oxide; lithium chloride / N,N-dimethyl-formamide / 18 h

2: palladium on carbon; hydrogen / ethanol / 0.5 h

3: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve; Air

With pyridine; pyridine N-oxide; palladium on carbon; hydrogen; copper diacetate; lithium chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Mukaiyama aldol condensation / 3: Suzuki coupling;

DOI:10.1021/jm101583w

Reference yield:

methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate → 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester (1283087-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / ethanol / 0.5 h

2: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve; Air

With pyridine; palladium on carbon; hydrogen; copper diacetate; In ethanol; dichloromethane; 2: Suzuki coupling;

DOI:10.1021/jm101583w

Reference yield: 73.0%

2-methylimidazole (693-98-1) + 3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester (1283087-62-6) → C22H25N3O2 (1401313-58-3)

Guidance literature:

With bis-(2-methyl-1H-imidazol-1-yl)methanone; In acetonitrile; for 24h; Reflux;

DOI:10.1016/j.bmc.2012.08.044

upstream raw materials:

4-nitrobenzaldehdye

Downstream raw materials:

3-imidazol-1-yl-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

methyl 2,2-dimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanoate

3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)-propionic acid

3-hydroxy-2,2,N-trimethyl-3-(4-phenylaminophenyl)propionamide

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