3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 1070437-07-8
• Molecular Formula: C₁₅H₁₄IN₃O₂S
• Molecular Weight: 427.266
• Mol file: 1070437-07-8.mol

Synonyms:3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine

Chemical Property of 3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine

There total 1 articles about 3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tolyl vinyl sulfone (5535-52-4) + 3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → 3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine (1070437-07-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃;

Reference yield: 70.0%

3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine (1070437-07-8) + lithium formate (556-63-8) → 1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (1070437-09-0)

Guidance literature:

3-iodo-1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine; lithium formate; With acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

With water; acetic acid;

upstream raw materials:

tolyl vinyl sulfone

3-iodo-1H-pyrazolo[3,4-b]pyridine

Downstream raw materials:

1-{2-[(4-methylphenyl)sulfonyl]ethyl}-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid