{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

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Chemical Name:{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol
CAS No.:875303-40-5
Molecular Formula:C₃₂H₅₀O₆Si₂
Molecular Weight:586.916
Hs Code.:

Synonyms:{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

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Chemical Property of {(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

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Technology Process of {(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

There total 5 articles about {(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875303-35-8
(E)-(S)-4-Hydroxy-4-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid tert-butyl ester

: 875303-40-5
{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N; DMAP

2: 100 percent / imidazole; DMAP / dimethylformamide / 50 °C

3: 95 percent / DIBAL-H; NaBH₄ / CH₂Cl₂; tetrahydrofuran; methanol

4: 99 percent / i-Pr₂NEt; Bu₄NI

5: 93 percent / NBS / dimethylsulfoxide; H₂O / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; N-Bromosuccinimide; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-918960

Reference yield:

: 875303-36-9
(E)-(S)-4-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-hydroxy-but-2-enoic acid tert-butyl ester

: 875303-40-5
{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / imidazole; DMAP / dimethylformamide / 50 °C

2: 95 percent / DIBAL-H; NaBH₄ / CH₂Cl₂; tetrahydrofuran; methanol

3: 99 percent / i-Pr₂NEt; Bu₄NI

4: 93 percent / NBS / dimethylsulfoxide; H₂O / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; N-Bromosuccinimide; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-918960

Reference yield:

: 875303-38-1
(E)-(S)-4-[(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-(tert-butyl-diphenyl-silanyloxy)-but-2-en-1-ol

: 875303-40-5
{(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / i-Pr₂NEt; Bu₄NI

2: 93 percent / NBS / dimethylsulfoxide; H₂O / 20 °C

With N-Bromosuccinimide; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide;
DOI:10.1055/s-2005-918960