Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester
CAS No.:128483-54-5
Molecular Formula:C₂₇H₂₇F₃N₂O₇S₂
Molecular Weight:612.648
Hs Code.:

Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

Synonyms:Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

There total 6 articles about Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 128466-33-1
Acetic acid (2R,6S)-3-[2-acetoxy-eth-(E)-ylidene]-12-(toluene-4-sulfonyl)-10-trifluoromethanesulfonyloxy-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-13-ylmethyl ester

: 128483-54-5
Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

Guidance literature:: With potassium carbonate; In methanol; for 0.166667h; Ambient temperature;

Reference yield:

: 23173-00-4
18-hydroxygardnutine

: 128483-54-5
Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₄ / tetrahydrofuran / 4 h / Heating

2: pyridine / 15 h / Ambient temperature

3: tetra-n-butylammonium hydrogensulfate, 50percent KOH / benzene / 2 h / Ambient temperature

4: 95 percent / AlCl₃, ethanethiol / CH₂Cl₂ / 7 h / -18 °C

5: 82 percent / Et₃N / CH₂Cl₂ / 0.25 h / -18 °C

6: 86 percent / 5percent K₂CO₃ / methanol / 0.17 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; ethanethiol; In tetrahydrofuran; methanol; dichloromethane; benzene;

Reference yield:

: 23173-03-7
Acetic acid (2R,6S)-3-[2-acetoxy-eth-(E)-ylidene]-10-methoxy-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-13-ylmethyl ester

: 128483-54-5
Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetra-n-butylammonium hydrogensulfate, 50percent KOH / benzene / 2 h / Ambient temperature

2: 95 percent / AlCl₃, ethanethiol / CH₂Cl₂ / 7 h / -18 °C

3: 82 percent / Et₃N / CH₂Cl₂ / 0.25 h / -18 °C

4: 86 percent / 5percent K₂CO₃ / methanol / 0.17 h / Ambient temperature

With potassium hydroxide; aluminium trichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; ethanethiol; In methanol; dichloromethane; benzene;