Technology Process of (1S,5R,6S)-6-Benzyl-3-oxa-bicyclo[3.1.0]hexan-2-one
There total 1 articles about (1S,5R,6S)-6-Benzyl-3-oxa-bicyclo[3.1.0]hexan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dirhodium(II) tetrakis(methyl 2-oxopyrrolidine-5(R)-carboxylate);
In
dichloromethane;
for 18h;
Title compound not separated from byproducts;
Heating;
DOI:10.1021/jm00088a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) trimethylaluminum / 1.) CH2Cl2, hexane, RT, 20 min, 2.) CH2Cl2, hexane, 40 deg C, 40 h
2: lithium hexamethyldisilazide / tetrahydrofuran / Ambient temperature
3: 8N Jones' reagent / acetone; ethanol / 2 h / 0 - 5 °C
4: 1-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC*HCl) / dimethylformamide / 24 h / Ambient temperature
With
jones' reagent; trimethylaluminum; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00088a005
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) trimethylaluminum / 1.) CH2Cl2, hexane, RT, 20 min, 2.) CH2Cl2, hexane, 40 deg C, 40 h
2: pyridinium chlorochromate / CH2Cl2 / 48 h / Ambient temperature
3: K2CO3 / methanol / 24 h / Ambient temperature
4: 8N Jones' reagent / acetone / 2 h / 0 - 5 °C
5: 1-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC*HCl) / dimethylformamide / 24 h / Ambient temperature
With
jones' reagent; trimethylaluminum; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00088a005
