(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

Base Information

Chemical Name:(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone
CAS No.:928842-59-5
Molecular Formula:C₃₆H₄₇NO₇Si
Molecular Weight:633.857
Hs Code.:

Synonyms:(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

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Technology Process of (S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

There total 4 articles about (S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928842-58-4
(S)-4-benzyl-3-[(S)-8-(tert-butyldiphenylsilyloxy)-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

: 928842-59-5
(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

Guidance literature:: (S)-4-benzyl-3-[(S)-8-(tert-butyldiphenylsilyloxy)-6-(methoxymethoxy)octanoyl]-2-oxazolidinone; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -75 ℃;

With oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; In tetrahydrofuran; toluene; at -75 ℃; Further stages.;
DOI:10.1271/bbb.70.712

Reference yield:

: 728944-00-1
(S)-methyl 8-tert-butyldiphenylsilyloxy-6-methoxymethoxyoctanoate

: 928842-59-5
(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. KOH / ethanol / 0 °C

2.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 0 °C

2.2: tetrahydrofuran / 0 °C

3.1: KHMDS / tetrahydrofuran; toluene / -75 °C

3.2: MoO₅*Py*HMPA / tetrahydrofuran; toluene / -75 °C

With potassium hydroxide; pivaloyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; ethanol; toluene;
DOI:10.1271/bbb.70.712

Reference yield:

: 928842-57-3
(S)-8-(tert-butyldiphenylsilyloxy)-6-(methoxymethoxy)octanoic acid

: 928842-59-5
(S)-4-benzyl-3-[(2S,6S)-8-(tert-butyldiphenylsilyloxy)-2-hydroxy-6-(methoxymethoxy)octanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 0 °C

1.2: tetrahydrofuran / 0 °C

2.1: KHMDS / tetrahydrofuran; toluene / -75 °C

2.2: MoO₅*Py*HMPA / tetrahydrofuran; toluene / -75 °C

With pivaloyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1271/bbb.70.712