2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

Base Information

Chemical Name:2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole
CAS No.:934989-91-0
Molecular Formula:C₂₉H₃₅NOSSi
Molecular Weight:473.755
Hs Code.:

Synonyms:2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

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Chemical Property of 2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

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Technology Process of 2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

There total 12 articles about 2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 934989-90-9
2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-prop-2-ynylthiazole

: 106-95-6
allyl bromide

: 934989-91-0
2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

Guidance literature:: With ethylmagnesium bromide; copper(I) bromide; In tetrahydrofuran; for 1h; Heating;
DOI:10.1002/ejoc.200600671

Reference yield:

: 934989-88-5
3-(tert-butyldiphenylsilyloxy)-2,2-dimethylpropanamide

: 934989-91-0
2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

Guidance literature:: Multi-step reaction with 7 steps

1: Lawessons reagent / dichloromethane / 24 h

2: tetrahydrofuran / 2 h / 20 °C

3: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

4: diisobutylaluminium hydride / diethyl ether / 1 h / -78 °C

5: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

6: indium(III) chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; hexane; dichloromethane / Heating

7: ethylmagnesium bromide; copper(I) bromide / tetrahydrofuran / 1 h / Heating

With Lawessons reagent; pyridine; indium(III) chloride; carbon tetrabromide; ethylmagnesium bromide; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic anhydride; copper(I) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/ejoc.200600671

Reference yield:

: 934989-99-8
ethyl 2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethyl]-4-hydroxy-4,5-dihydrothiazol-4-carboxylate

: 934989-91-0
2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]-4-hex-5-en-2-ynylthiazole

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

2: diisobutylaluminium hydride / diethyl ether / 1 h / -78 °C

3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

4: indium(III) chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; hexane; dichloromethane / Heating

5: ethylmagnesium bromide; copper(I) bromide / tetrahydrofuran / 1 h / Heating

With pyridine; indium(III) chloride; carbon tetrabromide; ethylmagnesium bromide; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic anhydride; copper(I) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/ejoc.200600671