1-Amino-1-phenylpropan-2-ol hydrochloride

Base Information

• Chemical Name: 1-Amino-1-phenylpropan-2-ol hydrochloride
• CAS No.: 102439-90-7
• Molecular Formula: C₉H₁₃NO*ClH
• Molecular Weight: 187.669
• European Community (EC) Number: 892-436-0
• Mol file: 102439-90-7.mol

Synonyms:1-amino-1-phenylpropan-2-ol hydrochloride;102439-90-7;1-AMINO-1-PHENYLPROPAN-2-OL HCL;1-amino-1-phenylpropan-2-ol;hydrochloride;SCHEMBL520234;VIOJYFJDMKDXOT-UHFFFAOYSA-N;CEA43990;SB44389;1-amino-1-phenylpropan-2-olhydrochloride;1-amino-1-phenyl-2-propanol hydrochloride;EN300-307651;Y13368;Z2588063686

Chemical Property of 1-Amino-1-phenylpropan-2-ol hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.0763918
• Heavy Atom Count: 12
• Complexity: 110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)N)O.Cl

Technology Process of 1-Amino-1-phenylpropan-2-ol hydrochloride

There total 3 articles about 1-Amino-1-phenylpropan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

C11H12Cl3NO → 1-amino-1-phenyl-propan-2-ol; hydrochloride (102439-90-7)

Guidance literature:

C₁₁H₁₂Cl₃NO; With N-iodo-succinimide; In 1,2-dichloro-ethane; at 110 ℃; for 3h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; at 20 ℃; for 5h; Inert atmosphere; Sealed tube;

DOI:10.1039/c7cc08897c

Reference yield:

(R)-N-(2-hydroxy-1-phenylpropyl)-2-methylpropane-2-sulfinamide → 1-amino-1-phenyl-propan-2-ol; hydrochloride (102439-90-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.6b00376

Reference yield:

→ 1-amino-1-phenyl-propan-2-ol; hydrochloride (102439-90-7)

Guidance literature:

With hydrogenchloride; sodium amalgam;

Downstream raw materials:

(4R,5S)-5-methyl-4-phenyloxazolidin-2-one

(4R,5R)-5-Methyl-4-phenyl-2-oxazolidinone