5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin

Base Information

• Chemical Name: 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin
• CAS No.: 386745-22-8
• Molecular Formula: C₂₁H₂₂N₂O₄S
• Molecular Weight: 398.483
• Mol file: 386745-22-8.mol

Synonyms:5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin

Chemical Property of 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin

There total 2 articles about 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 3-(2-phenylethyl)-2-thioxotetrahydro-4H-imidazol-4-one (287918-12-1) → 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin (386745-22-8)

Guidance literature:

With sodium acetate; In acetic acid; for 4h; Heating;

Reference yield:

Phenethyl isothiocyanate (2257-09-2) → 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin (386745-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH; pyridine / 1 h / 40 °C / pH 9

1.2: 68 percent / conc. HCl / 2 h / Heating

2.1: 78 percent / NaOAc / acetic acid / 4 h / Heating

With pyridine; sodium hydroxide; sodium acetate; In acetic acid;

Reference yield: 82.0%

5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin (386745-22-8) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → 5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-S-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-thiohydantoin

Guidance literature:

5-((Z)-3,4,5-trimethoxybenzylidene)-3-(2-phenylethyl)-2-thiohydantoin; With sodium hydride; In acetonitrile; at 20 ℃; for 0.5h;

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide; In acetonitrile; at 20 ℃; for 6h;

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

3-(2-phenylethyl)-2-thioxotetrahydro-4H-imidazol-4-one

Phenethyl isothiocyanate