(R)-1-N-Boc-3-(2-hydroxyethyl)piperidine

Base Information

• Chemical Name: (R)-1-N-Boc-3-(2-hydroxyethyl)piperidine
• CAS No.: 389889-62-7
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.32
• Hs Code.: 2933399090
• Mol file: 389889-62-7.mol

Synonyms:tert-Butyl(3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate;

Chemical Property of (R)-1-N-Boc-3-(2-hydroxyethyl)piperidine

Chemical Property:

• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.478
• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 149.8 °C
• PSA: 49.77000
• Density: 1.043 g/cm³
• LogP: 1.95380
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-N-Boc-piperidine-3-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-N-Boc-3-(2-hydroxyethyl)piperidine

There total 1 articles about (R)-1-N-Boc-3-(2-hydroxyethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl (3R)-3-(2-ethoxy-2-oxoethyl)tetrahydropyridine-1(2H)-carboxylate (188723-32-2) → t-butyl (3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate (389889-62-7)

Guidance literature:

t-butyl (3R)-3-(2-ethoxy-2-oxoethyl)tetrahydropyridine-1(2H)-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With water; sodium sulfate; In tetrahydrofuran; for 12h;

Reference yield: 96.0%

t-butyl (3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate (389889-62-7) → tert-butyl (R)-3-(2-oxoethyl)piperidine-1-carboxylate (1039361-81-3,278789-57-4)

Guidance literature:

t-butyl (3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 ℃; for 1h; Inert atmosphere; Schlenk technique;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 3.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acsmedchemlett.8b00030

upstream raw materials:

t-butyl (3R)-3-(2-ethoxy-2-oxoethyl)tetrahydropyridine-1(2H)-carboxylate

Downstream raw materials:

tert-butyl (R)-3-(2-oxoethyl)piperidine-1-carboxylate