N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

Base Information

Chemical Name:N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide
CAS No.:75971-27-6
Molecular Formula:C₃₇H₃₈FN₅O₄
Molecular Weight:635.738
Hs Code.:

Synonyms:N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

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Chemical Property of N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

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Technology Process of N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

There total 6 articles about N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 75971-27-6
N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 55 percent / sodium carbonate, potassium iodide / dimethylformamide / 2 h / 60 °C

4: H₂, ammonia / RaNi / methanol / 760 Torr / Ambient temperature

5: triethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With ammonia; hydrogen bromide; hydrogen; sodium carbonate; triethylamine; potassium iodide; RaNi; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 73735-20-3
4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

: 75971-27-6
N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, ammonia / RaNi / methanol / 760 Torr / Ambient temperature

2: triethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With ammonia; hydrogen; triethylamine; RaNi; In methanol; dichloromethane;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 75971-27-6
N-<2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>1-piperidinyl>ethyl>-4-methoxy-N-(4-methoxybenzoyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 55 percent / sodium carbonate, potassium iodide / dimethylformamide / 2 h / 60 °C

3: H₂, ammonia / RaNi / methanol / 760 Torr / Ambient temperature

4: triethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With ammonia; hydrogen bromide; hydrogen; sodium carbonate; triethylamine; potassium iodide; RaNi; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029