4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol
CAS No.:860437-83-8
Molecular Formula:C₂₆H₄₂O₃Si₂
Molecular Weight:458.789
Hs Code.:

4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butan-1-ol

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Chemical Property:

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

There total 1 articles about 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

: 860437-83-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Guidance literature:: 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 2h;
DOI:10.1021/ol0511833

Reference yield: 92.0%

: 860437-83-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 860438-10-4
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butylsulfanyl]-1-phenyl-1H-tetrazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol0511833

Reference yield:

: 860437-83-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

: 860437-87-2
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2.1: 82 percent / Mo₇O₂₄(NH₄)6*4H₂O; aq. H₂O₂ / ethanol / 18 h / 20 °C

3.1: 72 percent / KHMDS / tetrahydrofuran; toluene / -78 - 20 °C

4.1: 91 percent / H₂ / Pd/C / ethyl acetate / 48 h

5.1: DibalH / CH₂Cl₂; hexane / 6 h / -78 °C

5.2: 89 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 0 °C

With ammonium molybdate tetrahydrate; di-isopropyl azodicarboxylate; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; toluene; 1.1: Mitsunobu reaction / 3.1: Julia-Kocienski olefination;
DOI:10.1021/ol0511833