N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

Base Information

Chemical Name:N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine
CAS No.:258332-56-8
Molecular Formula:C₂₉H₃₁NO₅
Molecular Weight:473.569
Hs Code.:

Synonyms:N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

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Chemical Property of N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

Chemical Property:

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Technology Process of N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

There total 2 articles about N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1286711-12-3
N-[2-(4-tert-butyloxyphenyl)ethyl]glycine ethyl ester

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 258332-56-8
N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

Guidance literature:: N-[2-(4-tert-butyloxyphenyl)ethyl]glycine ethyl ester; With sodium hydroxide; In methanol; for 0.5h; Inert atmosphere;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm200006c

Reference yield:

: 157981-64-1
2-(4-tert-butyloxyphenyl)ethylamine

: 258332-56-8
N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 0.5 h / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm200006c

Reference yield:

: Fmoc-Leu-Wang resin

: 214750-72-8
N^α-Fmoc-N^ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-N^α-methyl-L-arginine

: 258332-56-8
N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine

: 71989-31-6
Fmoc-Pro-OH

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 187618-60-6
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 198561-07-8
Fmoc-L-propargyl-Gly-OH

: H-propargyl-Gly-N-Me-Arg-Lys-Pro-N-homo-Tyr-Ile-Leu-OH

Guidance literature:: Fmoc-Leu-Wang resin; With piperidine; In N,N-dimethyl-formamide; Wang resin Sealed tube; Microwave irradiation;

Fmoc-Ile-OH; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Wang resin Sealed tube; Microwave irradiation;

N^α-Fmoc-N^ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-N^α-methyl-L-arginine; N-(9-fluorenylmethyloxycarbonyl)-N-[2-(4-tert-butyloxyphenyl)ethyl]glycine; Fmoc-Pro-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Fmoc-L-propargyl-Gly-OH; Further stages;
DOI:10.1016/j.bmc.2015.01.053