2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

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Chemical Name:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid
CAS No.:512784-02-0
Molecular Formula:C₃₁H₂₆F₃N₃O₆
Molecular Weight:593.559
Hs Code.:

2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-<i>N</i>-(3-trifluoromethyl-benzyl)-malonamic acid

Synonyms:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

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Chemical Property of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

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Technology Process of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

There total 7 articles about 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 195310-62-4
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

: 512784-02-0
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

Guidance literature:: With formic acid; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: (3-phenyl-allylideneamino)-acetic acid tert-butyl ester

: 512784-02-0
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: 56 percent / tetrahydrofuran

3.1: 82 percent / tetrahydrofuran / Heating

4.1: 100 percent / formic acid / 20 °C

With formic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 512784-02-0
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: desiccating agent / CH₂Cl₂ / 20 °C

2.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3.2: 56 percent / tetrahydrofuran

4.1: 82 percent / tetrahydrofuran / Heating

5.1: 100 percent / formic acid / 20 °C

With formic acid; desiccating agent; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031