4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Base Information

Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate
CAS No.:1362688-84-3
Molecular Formula:C₃₄H₄₄FN₆O₈P
Molecular Weight:714.731
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Suppliers and Price of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

There total 3 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₅₂FN₆O₁₀P

: 1362688-84-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: C₃₉H₅₂FN₆O₁₀P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1362688-84-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 1309464-60-5
C₁₈H₁₈BrFO₂

: 287178-39-6
N-tert-Butyloxycarbonyl-L-isoleucine 2-bromoethyl ester

: 1362688-84-3
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(2-fluorobiphenyl-4-yl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

1.2: 40 - 50 °C

1.3: 80 - 100 °C

2.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

2.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; phosphoric acid; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013