(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

Base Information

Chemical Name:(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide
CAS No.:1607457-30-6
Molecular Formula:C₂₇H₂₃F₆N₃O₄
Molecular Weight:567.488
Hs Code.:

Synonyms:(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

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Chemical Property of (2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

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Technology Process of (2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

There total 4 articles about (2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607457-46-4
C₁₇H₁₈N₂O₃

: 790-75-0
N-(3,5-bis-trifluoromethyl-phenyl)-2-chloro-acetamide

: 1607457-30-6
(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

Guidance literature:: C₁₇H₁₈N₂O₃; With potassium carbonate; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

N-(3,5-bis-trifluoromethyl-phenyl)-2-chloro-acetamide; In acetone; for 10h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.03.019

Reference yield:

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid

: 1607457-30-6
(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

3.2: 10 h / Inert atmosphere; Reflux

With potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmc.2014.03.019

Reference yield:

: 621-59-0
isovanillin

: 1607457-30-6
(2E)-N-(2-amino-4-methylphenyl)-3-[3-(2-{[3,5-bis(trifluoromethyl)phenyl]amino}-2-oxoethoxy)-4-methoxyphenyl]acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 4 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

4.2: 10 h / Inert atmosphere; Reflux

With pyridine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; acetone; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.bmc.2014.03.019