(Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione

Base Information

• Chemical Name: (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione
• CAS No.: 1208535-06-1
• Molecular Formula: C₁₀H₇NO₄S
• Molecular Weight: 237.236
• Mol file: 1208535-06-1.mol

Synonyms:(Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione

Chemical Property of (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione

There total 2 articles about (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

thiazoline-2,4-dione (2295-31-0) + 2,4-Dihydroxybenzaldehyde (95-01-2) → (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione (1208535-06-1)

Guidance literature:

With ethylenediamine; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00610

Reference yield: 45.4%

→ (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione (1208535-06-1)

Guidance literature:

With piperidine; In ethanol; for 24h; Reflux;

Reference yield: 62.0%

4-(bromomethyl)-7-hydroxy-2H-chromen-2-one (161798-25-0) + (Z)-5-(2-hydroxy-4-methoxybenzylidene)thiazolidine-2,4-dione (1208535-06-1) → (Z)-5-(2,4-dihydroxybenzylidene)-3-[(7-hydroxy-2-oxo-2H-chromen-4-yl)methyl]thiazolidine-2,4-dione (1307299-77-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1515/znb-2011-0210

upstream raw materials:

thiazoline-2,4-dione

2,4-Dihydroxybenzaldehyde

Downstream raw materials:

(Z)-5-(2,4-dihydroxybenzylidene)-3-[(7-hydroxy-2-oxo-2H-chromen-4-yl)methyl]thiazolidine-2,4-dione