(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

Base Information

Chemical Name:(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide
CAS No.:910534-97-3
Molecular Formula:C₂₂H₂₆F₂N₂O₃S
Molecular Weight:436.523
Hs Code.:

Synonyms:(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

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Chemical Property of (Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

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Technology Process of (Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

There total 4 articles about (Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 910534-96-2
(Z)-3-[4-(t-butyl)phenyl]-2-fluoro-2-butenoic acid

: 53473-36-2
3-(4-trifluoromethylphenyl)propionic acid

: 910534-97-3
(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

Guidance literature:: (Z)-3-[4-(t-butyl)phenyl]-2-fluoro-2-butenoic acid; With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; for 2h;

3-(4-trifluoromethylphenyl)propionic acid; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 910534-95-1
(Z)-ethyl 3-(4-tert-butylphenyl)-2-fluorobut-2-enoate

: 910534-97-3
(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C

2: triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran / 14 h

With 4-methyl-morpholine; lithium hydroxide monohydrate; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; water;
DOI:10.1007/s12272-013-0228-x

Reference yield:

: 943-27-1
4'-t-butylacetophenone

: 910534-97-3
(Z)-3-(4-tert-butylphenyl)-2-fluoro-N-[3-fluoro-4-(methylsulfonamido)benzyl]but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C

3.1: triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran / 14 h

With 4-methyl-morpholine; lithium hydroxide monohydrate; sodium hydride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; water; mineral oil;
DOI:10.1007/s12272-013-0228-x