Thiazol-2-ylmethanamine

Base Information

• Chemical Name: Thiazol-2-ylmethanamine
• CAS No.: 55661-33-1
• Molecular Formula: C4H6N2S
• Molecular Weight: 114.171
• Hs Code.: 2934100090
• European Community (EC) Number: 672-514-9
• DSSTox Substance ID: DTXSID80373401
• Wikidata: Q72508276
• Mol file: 55661-33-1.mol

Synonyms:Thiazol-2-ylmethanamine;55661-33-1;2-Thiazolemethanamine;1,3-thiazol-2-ylmethylamine;1,3-thiazol-2-ylmethanamine;2-(aminomethyl)thiazole;2-AMINOMETHYLTHIAZOLE;C-THIAZOL-2-YL-METHYLAMINE;(1,3-thiazol-2-yl)methanamine;MFCD02854204;2-Aminomethyl-1,3-thiazole;aminomethylthiazole;2-aminomethyl-thiazole;Thiazole, 2-aminomethyl;thiazol-2-ylmethyl-amine;Thiazol-2-yl-methylamine;(thiazol-2-ylmethyl)-amine;SCHEMBL69929;(2-THIAZOLYL)METHYLAMINE;2-(Aminomethyl)thiazole, 97%;(1,3-thiazol-2-ylmethyl)amine;DTXSID80373401;JOZSYOPADROCMP-UHFFFAOYSA-N;1-(1,3-thiazol-2-yl)methanamine;1-(1,3-thiazol-2-yl)methylamine;BCP10504;STK500770;AKOS005171216;CS-W013635;PB20005;SY005981;TS-01582;AM20100366;BB 0216364;FT-0647187;EN300-42053;J-503946;Z1198107502;2-Aminomethylthiazoledihydrochloride

Chemical Property of Thiazol-2-ylmethanamine

Chemical Property:

• Vapor Pressure: 0.0085mmHg at 25°C
• Melting Point: 180-185 °C
• Refractive Index: n20/D1.569
• Boiling Point: 191.1 °C at 760 mmHg
• PKA: 7.24±0.40(Predicted)
• Flash Point: 69.366 °C
• PSA: 67.15000
• Density: 1.239 g/cm³
• LogP: 1.30210
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 114.02516937
• Heavy Atom Count: 7
• Complexity: 57.7

Purity/Quality:

97% ^*data from raw suppliers

2-(Aminomethyl)thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=N1)CN
• Uses: (2-Thiazolyl)methylamine is a useful compound in the preparation of cephalosporins

Technology Process of Thiazol-2-ylmethanamine

There total 8 articles about Thiazol-2-ylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(N-(benzyloxycarbonyl)aminomethyl)thiazole → 2-(aminomethyl)thiazole (55661-33-1)

Guidance literature:

With hydrogen bromide; In acetic acid; for 1h; Ambient temperature;

DOI:10.1016/0040-4020(95)00828-V

Reference yield: 80.0%

1,3-thiazole-2-carbaldehyde oxime (13838-77-2) → 2-(aminomethyl)thiazole (55661-33-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 20h;

DOI:10.1055/s-1996-4259

Reference yield: 72.0%

thiazol-2-yl-methylazide (171268-82-9) + water (7732-18-5) → 2-(aminomethyl)thiazole (55661-33-1)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran;

upstream raw materials:

2-chloroethanal

N-(2-amino-2-thioxoethyl)benzamide

thiourea

chloroacetone

Downstream raw materials:

2-amino-3-(2-thiazolyl)propanoic acid

C₆H₈N₂SO

C₁₆H₁₃F₃N₄O₂S₂

(Z)-2-{1-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}-N-(thiazol-2-ylmethyl)acetamide