3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine

Base Information

• Chemical Name: 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine
• CAS No.: 182934-49-2
• Molecular Formula: C₃₀H₃₀FN₃O₆
• Molecular Weight: 547.583
• Mol file: 182934-49-2.mol

Synonyms:3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine

Chemical Property of 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine

There total 1 articles about 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-{(2R,3R,4R,5S)-4-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione → 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine (182934-49-2)

Guidance literature:

With pyridine; hydrogen sulfide; at 20 ℃; for 18h;

DOI:10.1039/b110603c

Reference yield: 59.0%

4-nitrophenyl sulfurochloridate (18997-12-1) + 3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine (182934-49-2) → 4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine-3'-sulfamate

Guidance literature:

With 4-nitro-phenol; 4 A molecular sieve; triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1039/b110603c

Reference yield:

3'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridine (182934-49-2) → 5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridin-3'-ylsulfamido-[3'(N)->5'(N)]-5'-deoxythymidine (428506-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

2: 97 percent / TBAF / tetrahydrofuran / 1.5 h

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

DOI:10.1039/b110603c

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2',3'-dideoxyuridin-3'-ylsulfamido-[3'(N)->5'(N)]-5'-deoxythymidine