2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane

Base Information

• Chemical Name: 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane
• CAS No.: 103752-09-6
• Molecular Formula: C₁₂H₁₈NO₃P
• Molecular Weight: 255.254
• Mol file: 103752-09-6.mol

Synonyms:2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane

Chemical Property of 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane

There total 3 articles about 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxy-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane (103752-15-4) → 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane (103752-09-6)

Guidance literature:

With dinitrogen tetraoxide; In dichloromethane; at -20 ℃;

DOI:10.1021/ja00281a037

Reference yield:

N-phenyl-2-(hydroxymethyl)-2-methylpropylamine (94844-02-7) → 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane (103752-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 77.5 percent / phosphorus trichloride, triethylamine / diethyl ether / Ambient temperature

2: 90.9 percent / triethylamine / diethyl ether / 0 deg C, then room temp.

3: 95 percent / dinitrogen tetroxide / CH₂Cl₂ / -20 °C

With dinitrogen tetraoxide; triethylamine; phosphorus trichloride; In diethyl ether; dichloromethane;

DOI:10.1021/ja00281a037

Reference yield:

2-chloro-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane (103752-14-3) → 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane (103752-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.9 percent / triethylamine / diethyl ether / 0 deg C, then room temp.

2: 95 percent / dinitrogen tetroxide / CH₂Cl₂ / -20 °C

With dinitrogen tetraoxide; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/ja00281a037

upstream raw materials:

2-methoxy-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane

N-phenyl-2-(hydroxymethyl)-2-methylpropylamine

2-chloro-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane