N--4-amidoximo-D-phenylalanine piperidide

Base Information

Chemical Name:N--4-amidoximo-D-phenylalanine piperidide
CAS No.:172267-47-9
Molecular Formula:C₃₆H₄₅N₅O₈S
Molecular Weight:707.848
Hs Code.:

N-<N'-(4-methoxy-2,3,5-trimethylphenylsulfonyl)-β-(O-benzyl)-α-L-aspartyl>-4-amidoximo-D-phenylalanine piperidide

Synonyms:N--4-amidoximo-D-phenylalanine piperidide

Suppliers and Price of N--4-amidoximo-D-phenylalanine piperidide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--4-amidoximo-D-phenylalanine piperidide

Chemical Property:

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Technology Process of N--4-amidoximo-D-phenylalanine piperidide

There total 13 articles about N--4-amidoximo-D-phenylalanine piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 172267-46-8
N--4-cyano-D-phenylalanine piperidide

: 172267-47-9
N--4-amidoximo-D-phenylalanine piperidide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; for 5h; Heating;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 80745-07-9
4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

: 172267-47-9
N--4-amidoximo-D-phenylalanine piperidide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / iPr₂NH / dimethylformamide; H₂O / 4 h / 0 °C

2: 87 percent / thionyl chloride / ethyl acetate / 1.) 0 deg C to 20 deg C, 1.5 h; 2.) 20 deg C, 45 min

3: K₂CO₃ / dimethylformamide / 4 h / 20 °C

4: 76 percent / MEPA / ethyl acetate / 16 h / 25 °C

5: 51 percent / hydroxylamine hydrochloride, NEt₃ / ethanol / 5 h / Heating

With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; triethylamine; diisopropylamine; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00765-Z

Reference yield:

: 110-89-4
piperidine

: 172267-47-9
N--4-amidoximo-D-phenylalanine piperidide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / MEPA / ethyl acetate / 1 h / 25 °C

2: 85 percent / aq. HCl / 2 h / 80 °C

3: 76 percent / MEPA / ethyl acetate / 16 h / 25 °C

4: 51 percent / hydroxylamine hydrochloride, NEt₃ / ethanol / 5 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; triethylamine; In ethanol; ethyl acetate;
DOI:10.1016/0040-4020(95)00765-Z