3-Acetylamino-2-methoxypyridine

Base Information

• Chemical Name: 3-Acetylamino-2-methoxypyridine
• CAS No.: 51468-07-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 51468-07-6.mol

Synonyms:N-(2-methoxypyridin-3-yl)acetamide

Chemical Property of 3-Acetylamino-2-methoxypyridine

Chemical Property:

• Boiling Point: 296℃
• Flash Point: 133℃
• Density: 1.189
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Methoxypyridin-3-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Acetylamino-2-methoxypyridine

There total 3 articles about 3-Acetylamino-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2-methoxypyridine (20265-38-7) + acetic anhydride (108-24-7) → N-(2-methoxypyridin-3-yl)acetamide (51468-07-6)

Guidance literature:

With perchloric acid;

Reference yield:

2-methoxy-3-nitropyridine (20265-35-4) → N-(2-methoxypyridin-3-yl)acetamide (51468-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 - 27 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

→ N-(2-methoxypyridin-3-yl)acetamide (51468-07-6)

Guidance literature:

3-Acetamino-6-brom-2-methoxy-pyridin in Me., Pd-Kohle, Na-Acetat, H2;

DOI:10.1002/hlca.19640470205

upstream raw materials:

3-amino-2-methoxypyridine

acetic anhydride

2-methoxy-3-nitropyridine