4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione

Base Information

• Chemical Name: 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione
• CAS No.: 75737-04-1
• Molecular Formula: C₁₆H₁₉ClN₂S
• Molecular Weight: 306.859

Synonyms:4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione

Chemical Property of 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione

Chemical Property:

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Technology Process of 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione

There total 4 articles about 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

cycloactanone (502-49-8) + 4-chlorobenzaldehyde (104-88-1) + thiourea (17356-08-0) → 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione (75737-04-1)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

DOI:10.1002/ejoc.200400845

Reference yield:

cycloactanone (502-49-8) → 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione (75737-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 5 h / Heating

2: KOH / ethanol / 3 h / Heating

With potassium hydroxide; sodium hydroxide; In ethanol;

DOI:10.1021/je00023a030

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 4-(4-Chloro-phenyl)-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione (75737-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 5 h / Heating

2: KOH / ethanol / 3 h / Heating

With potassium hydroxide; sodium hydroxide; In ethanol;

DOI:10.1021/je00023a030

upstream raw materials:

2-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-cyclooctanone

thiourea

cycloactanone

4-chlorobenzaldehyde

Downstream raw materials:

2-Acetyl-4-(4-chloro-phenyl)-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one

4-(4-Chloro-phenyl)-2-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one

4-(4-Chloro-phenyl)-2-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one

4-(4-Chloro-phenyl)-2-[1-phenyl-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one

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