ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate

Base Information

• Chemical Name: ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate
• CAS No.: 170280-64-5
• Molecular Formula: C₂₅H₂₇NO₄S₂
• Molecular Weight: 469.626
• Mol file: 170280-64-5.mol

Synonyms:ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate

Chemical Property of ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate

There total 6 articles about ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

ethyl (RS)-4-[2-carbamoyl-5-(thien-3-yl-methoxy)phenoxy]-4-(2-methylphenyl)butanoate (170280-47-4) → ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate (170280-64-5)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jm9707131

Reference yield:

Lawessons reagent (19172-47-5,94367-93-8) + ethyl (RS)-4-[2-carbamoyl-5-(thien-3-yl-methoxy)phenoxy]-4-(2-methylphenyl)butanoate (170280-47-4) → ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate (170280-64-5)

Guidance literature:

In tetrahydrofuran;

Reference yield:

2-methylphenyl aldehyde (529-20-4) → ethyl (RS)-4-(2-methylphenyl)-4-[5-(thien-3-ylmethoxy)-2-thiocarbamoyl-phenoxy]butanoate (170280-64-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / TiCl₄ / CH₂Cl₂ / 2 h / Ambient temperature

2: K₂CO₃, KI / butan-2-one / 48 h / Heating

3: 47 percent / Lawesson's reagent / tetrahydrofuran / 5 h / Ambient temperature

With Lawessons reagent; titanium tetrachloride; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; butanone;

DOI:10.1021/jm9707131

upstream raw materials:

ethyl (RS)-4-[2-carbamoyl-5-(thien-3-yl-methoxy)phenoxy]-4-(2-methylphenyl)butanoate

2-methylphenyl aldehyde

ethyl (RS)-4-chloro-4-(2-methylphenyl)butanoate

methyl 2-hydroxy-4-(thien-3-ylmethoxy)benzoate

Downstream raw materials:

4-[2-(1H-Imidazol-2-yl)-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-tolyl-butyric acid ethyl ester