N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine

Base Information

• Chemical Name: N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine
• CAS No.: 1216815-14-3
• Molecular Formula: C₁₉H₂₃N₅O₂
• Molecular Weight: 353.424

Synonyms:N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine

Chemical Property of N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine

Chemical Property:

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Technology Process of N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine

There total 1 articles about N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-{6-methoxy-4-[(4-methoxy-phenyl)methylamino]quinazolin-2-ylamino}ethyl)carbamic acid tert-butyl ester (1216815-16-5) → N2-(2-amino-ethyl)-6-methoxy-N4-(4-methoxy-phenyl)-N4-methyl-quinazoline-2,4-diamine (1216815-14-3)

Guidance literature:

(2-{6-methoxy-4-[(4-methoxy-phenyl)methylamino]quinazolin-2-ylamino}ethyl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

potassium cyanate (590-28-3) + N2-(2-amino-ethyl)-6-methoxy-N4-(4-methoxy-phenyl)-N4-methyl-quinazoline-2,4-diamine (1216815-14-3) → (2-{6-methoxy-4-[(4-methoxy-phenyl)-methyl-amino]-quinazolin-2-ylamino}-ethyl)-urea (1217306-07-4)

Guidance literature:

potassium cyanate; N₂-(2-amino-ethyl)-6-methoxy-N₄-(4-methoxy-phenyl)-N₄-methyl-quinazoline-2,4-diamine; With hydrogenchloride; In methanol; water; at 20 ℃; for 18h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

N2-(2-amino-ethyl)-6-methoxy-N4-(4-methoxy-phenyl)-N4-methyl-quinazoline-2,4-diamine (1216815-14-3) + methyl chloroformate (79-22-1) → (2-{6-methoxy-4-[(4-methoxy-phenyl)methylamino]quinazolin-2-ylamino}ethyl)carbamic acid methyl ester (1217306-11-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

(2-{6-methoxy-4-[(4-methoxy-phenyl)methylamino]quinazolin-2-ylamino}ethyl)carbamic acid tert-butyl ester

Downstream raw materials:

(2-{6-methoxy-4-[(4-methoxy-phenyl)-methyl-amino]-quinazolin-2-ylamino}-ethyl)-urea

(2-{6-methoxy-4-[(4-methoxy-phenyl)methylamino]quinazolin-2-ylamino}ethyl)carbamic acid methyl ester

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