methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate

Base Information

• Chemical Name: methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate
• CAS No.: 1590361-16-2
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 1590361-16-2.mol

Synonyms:methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate

Chemical Property of methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate

There total 4 articles about methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-tert-butoxycarbonyl-N-phenethylhydroxylamine + bromoacetic acid methyl ester (96-32-2) → methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate (1590361-16-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ja5018442

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate (1590361-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja5018442

Reference yield:

(benzyloxy)carbamic acid 1,1-dimethylethyl ester (105340-85-0) → methyl 2-(N-tert-butoxycarbonyl-N-phenethylamino)oxyacetate (1590361-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja5018442

upstream raw materials:

bromoacetic acid methyl ester

O-benzoyl-N-tert-butoxycarbonyl-N-phenethylhydroxylamine

(benzyloxy)carbamic acid 1,1-dimethylethyl ester

1-phenyl-2-bromoethane

Downstream raw materials:

methyl 2-(phenethylamino)oxyacetate