Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

Base Information

Chemical Name:Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate
CAS No.:174487-68-4
Molecular Formula:C₂₈H₁₈F₅N₃O₃
Molecular Weight:539.461
Hs Code.:

Synonyms:Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

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Chemical Property of Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

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Technology Process of Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

There total 3 articles about Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 14533-84-7
pentafluorophenyl trifloroacetate

: 174487-71-9
4-{N-[(6R/6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

: 174487-68-4
Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

Guidance literature:: With pyridine; In N,N-dimethyl acetamide; at 20 ℃; for 4h;
DOI:10.1021/jm991119p

Reference yield:

: 157701-04-7
N-(4-{N-[(6RS)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid

: 174487-68-4
Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.913 g / carboxypeptidase G₂; aq. tris-HCl buffer; ZnCl₂ / 69 h / 37 °C / pH 7.3

2: 79 percent / pyridine / N,N-dimethyl-acetamide / 4 h / 20 °C

With pyridine; Tris-HCl buffer; carboxypeptidase G₂; zinc(II) chloride; In N,N-dimethyl acetamide;
DOI:10.1021/jm991119p