(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

Base Information

Chemical Name:(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether
CAS No.:127733-25-9
Molecular Formula:C₂₇H₅₂O₄Si₂
Molecular Weight:496.878
Hs Code.:

Synonyms:(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

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Chemical Property of (3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

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Technology Process of (3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

There total 9 articles about (3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 127733-24-8
(3R,6S)-7-Benzyloxy-3-hydroxy-6-methylheptyl tert-Butyldimethylsilyl Ether

: 127733-25-9
(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 95338-04-8,110171-85-2,130659-83-5,95337-97-6
(2-((S)-oxiran-2-yl)ethoxy)(tert-butyl)dimethylsilane

: 127733-25-9
(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi, 2) HMPA / 1) hexane, THF, -78 deg C, 20 min, 2) THF, 0 deg C, 2 h

2: 83 percent / Na amalgam / ethanol / 5 h / Ambient temperature

3: 91 percent / i-Pr₂EtN / CH₂Cl₂ / 5 h / 40 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jo00046a008

Reference yield:

: 127733-22-6
(2R)-1-benzyloxy-2-methyl-3-(phenylsulfonyl)propane

: 127733-25-9
(3R,6S)-7-(Benzyloxy)-3-<<2-(trimethylsilyl)ethoxy>methoxy>-6-methylheptyl tert-Butyldimethylsilyl Ether

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi, 2) HMPA / 1) hexane, THF, -78 deg C, 20 min, 2) THF, 0 deg C, 2 h

2: 83 percent / Na amalgam / ethanol / 5 h / Ambient temperature

3: 91 percent / i-Pr₂EtN / CH₂Cl₂ / 5 h / 40 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jo00046a008