O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Base Information

Chemical Name:O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate
CAS No.:874292-21-4
Molecular Formula:C₄₀H₅₂N₃O₈P
Molecular Weight:733.842
Hs Code.:

Synonyms:O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

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Chemical Property of O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

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Technology Process of O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

There total 6 articles about O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874292-14-5
O-benzyl hex-2-en-1-yl(aminomethyl)phosphinate

: 939984-68-6
(S)-2-((S)-4-Benzyloxycarbonyl-4-benzyloxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 874292-21-4
O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm050922i

Reference yield:

: 874291-94-8
((E)-Hex-2-enyl)-phosphinic acid

: 874292-21-4
O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / tetrahydrofuran / 20 °C

2: 74 percent / BF₃*Et₂O / toluene / 72 h / 20 °C

3: 94 percent / trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

4: triethylamine / dimethylformamide / 16 h / 20 °C

With dmap; boron trifluoride diethyl etherate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050922i

Reference yield:

: 874292-00-9
hex-2-en-1-ylphosphinic acid benzyl ester

: 874292-21-4
O-benzyl hex-2-en-1-yl-[[(N-benzyloxy-L-γ-glutamyl(α-benzyl ester)-L-leucyl)amino]methyl]phosphinate

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / BF₃*Et₂O / toluene / 72 h / 20 °C

2: 94 percent / trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

3: triethylamine / dimethylformamide / 16 h / 20 °C

With boron trifluoride diethyl etherate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050922i