2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

Base Information

Chemical Name:2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride
CAS No.:1089277-92-8
Molecular Formula:C₃₀H₃₂Cl₂F₃N₃O₅S
Molecular Weight:674.568
Hs Code.:

2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

Synonyms:2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

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Chemical Property of 2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

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Technology Process of 2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

There total 4 articles about 2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.8%

: 1089187-35-8
2,2-dimethyl-5-amino-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-2,3-dihydro-benzofuran

: 5402-73-3
2,5-dichlorobenzenesulphonyl chloride

: 1089277-92-8
2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 52h;

Reference yield:

: 113194-07-3
2,2-dimethyl-5-nitro-2,3-dihydro-benzofuran-7-ol

: 1089277-92-8
2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / Heating / reflux

2: sodium hydroxide / water / 8.5 h / Heating / reflux

3: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

4: pyridine / dichloromethane / 52 h / 0 - 20 °C

With pyridine; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;

Reference yield:

: 1089187-62-1
2,2-dimethyl-5-nitro-7-(2-chloro-ethoxy)-2,3-dihydro-benzofuran

: 1089277-92-8
2,5-dichloro-phenylsulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl}-amide dihydro-chloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 8.5 h / Heating / reflux

2: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

3: pyridine / dichloromethane / 52 h / 0 - 20 °C

With pyridine; sodium hydroxide; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;