C₁₃H₁₃F₃N₂O₃

Base Information

• Chemical Name: C₁₃H₁₃F₃N₂O₃
• CAS No.: 1227306-92-4
• Molecular Formula: C₁₃H₁₃F₃N₂O₃
• Molecular Weight: 302.253
• Mol file: 1227306-92-4.mol

Synonyms:C₁₃H₁₃F₃N₂O₃

Chemical Property of C₁₃H₁₃F₃N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₃F₃N₂O₃

There total 6 articles about C₁₃H₁₃F₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

C16H17F3N2O3 → C13H13F3N2O3 (1227306-92-4)

Guidance literature:

With oxygen; ozone; In methanol; dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ml300209g

Reference yield:

C16H19F3N2O2 (1227306-91-3) → C13H13F3N2O3 (1227306-92-4)

Guidance literature:

C₁₆H₁₉F₃N₂O₂; With ozone; In methanol; dichloromethane; at -78 ℃; for 1h;

With dimethylsulfide; In methanol; dichloromethane;

Reference yield:

C22H34F3NO3Si (1227306-88-8) → C13H13F3N2O3 (1227306-92-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2-chloropropionyl chloride / methanol / 20 °C / Inert atmosphere

2.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 20 - 80 °C / Inert atmosphere

3.1: hydrazine hydrate / methanol; dichloromethane / 2 h / 20 °C / Inert atmosphere; Acidic conditions

3.2: 80 °C

4.1: ozone; oxygen / methanol; dichloromethane / 1 h / -78 °C / Inert atmosphere

With hydrazine hydrate; 2-chloropropionyl chloride; tributylphosphine; oxygen; ozone; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; 2.1: |Mitsunobu Displacement;

DOI:10.1021/ml300209g

upstream raw materials:

C₁₆H₁₉F₃N₂O₂

C₂₂H₃₄F₃NO₃Si

C₂₄H₂₃F₃N₂O₅

C₁₇H₂₈F₃NO₂Si

Downstream raw materials:

C₂₅H₂₃F₃N₄O₃