(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

Base Information

Chemical Name:(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester
CAS No.:194734-19-5
Molecular Formula:C₃₈H₅₅O₁₀PSi
Molecular Weight:730.908
Hs Code.:

(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

Synonyms:(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

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Chemical Property of (3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

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Technology Process of (3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

There total 10 articles about (3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150-76-5
4-methoxy-phenol

: 194734-19-5
(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DEAD, Ph₃P / CH₂Cl₂ / Ambient temperature

2: H₂ / Pd(C) / methanol

3: 1.) MsCl, Et₃N, 2.) NaOMe / 1.) CH₂Cl₂, -10 deg C, 2.) MeOH

4: 95 percent / diethyl ether / Ambient temperature

5: Dowex-50(H+)

6: pyridine / Ambient temperature

7: 1.) NMO, OsO₄, 2.) H₅IO₆ / 1.) t-BuOH, H₂O

8: tetrahydrofuran / -78 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; DOWEX-50(H+); hydrogen; sodium methylate; methanesulfonyl chloride; periodic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)01347-6

Reference yield:

: 157116-97-7
Acetic acid (1R,2S,3R,4R,5R)-4-allyl-2-benzyloxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 194734-19-5
(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Cy₂BH, 2.) H₂O₂, NaHCO₃ / 1.) THF

2: DEAD, Ph₃P / CH₂Cl₂ / Ambient temperature

3: H₂ / Pd(C) / methanol

4: 1.) MsCl, Et₃N, 2.) NaOMe / 1.) CH₂Cl₂, -10 deg C, 2.) MeOH

5: 95 percent / diethyl ether / Ambient temperature

6: Dowex-50(H+)

7: pyridine / Ambient temperature

8: 1.) NMO, OsO₄, 2.) H₅IO₆ / 1.) t-BuOH, H₂O

9: tetrahydrofuran / -78 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; DOWEX-50(H+); bis(cyclohexanyl)borane; hydrogen; dihydrogen peroxide; sodium methylate; sodium hydrogencarbonate; methanesulfonyl chloride; periodic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)01347-6

Reference yield:

: Acetic acid (1R,2S,3R,4R,5R)-2-benzyloxy-4-(3-hydroxy-propyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 194734-19-5
(3-{(2S,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-6-methoxy-5-[3-(4-methoxy-phenoxy)-propyl]-tetrahydro-pyran-3-yl}-2-hydroxy-propyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DEAD, Ph₃P / CH₂Cl₂ / Ambient temperature

2: H₂ / Pd(C) / methanol

3: 1.) MsCl, Et₃N, 2.) NaOMe / 1.) CH₂Cl₂, -10 deg C, 2.) MeOH

4: 95 percent / diethyl ether / Ambient temperature

5: Dowex-50(H+)

6: pyridine / Ambient temperature

7: 1.) NMO, OsO₄, 2.) H₅IO₆ / 1.) t-BuOH, H₂O

8: tetrahydrofuran / -78 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; DOWEX-50(H+); hydrogen; sodium methylate; methanesulfonyl chloride; periodic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)01347-6