5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

Base Information

Chemical Name:5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole
CAS No.:1033574-41-2
Molecular Formula:C₁₇H₁₁BrClF₃N₂O
Molecular Weight:431.639
Hs Code.:

Synonyms:5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

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Chemical Property of 5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

Chemical Property:

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Technology Process of 5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

There total 7 articles about 5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 106-41-2
4-bromo-phenol

: 1033586-28-5
5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

: 1033574-41-2
5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 80 - 85 ℃; for 20h;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033574-41-2
5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 h / 80 - 85 °C

With dmap; diisobutylaluminium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 1033574-41-2
5-(4-bromophenoxymethyl)-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 18 h / 80 °C

2: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

3: hydrogenchloride / dichloromethane; water

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

5: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

6: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 h / 80 - 85 °C

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; diisobutylaluminium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;