methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

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Chemical Name:methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate
CAS No.:1562995-69-0
Molecular Formula:C₁₉H₁₈FN₃O₃
Molecular Weight:355.369
Hs Code.:

Synonyms:methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

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Chemical Property of methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

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Technology Process of methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

There total 2 articles about methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603122-84-5
[2-fluoro-4-(methoxycarbonyl)phenyl]boronic acid

: 1562995-68-9
3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridine

: 1562995-69-0
methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 120 ℃; for 6h; Inert atmosphere;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1562995-69-0
methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene; 2: |Suzuki Coupling;

Reference yield:

: 1562995-69-0
methyl 3-fluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

: 1562995-11-2
4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 14 h / Reflux

2: dmap; triethylamine / dichloromethane / 3 h / 40 °C

3: water; lithium hydroxide / tetrahydrofuran / 2 h / 30 °C

With hydrogenchloride; dmap; water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;