3-(4-BROMO-2-THIENYL)ACRYLIC ACID

Base Information

• Chemical Name: 3-(4-BROMO-2-THIENYL)ACRYLIC ACID
• CAS No.: 144558-44-1
• Molecular Formula: C7H5 Br O2 S
• Molecular Weight: 233.08
• Mol file: 144558-44-1.mol

Synonyms:3-(4-Bromo-2-thienyl)acrylicacid

Chemical Property of 3-(4-BROMO-2-THIENYL)ACRYLIC ACID

Chemical Property:

• PSA: 65.54000
• LogP: 2.60840

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Bromo-thiophen-2-yl)-acrylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BROMO-2-THIENYL)ACRYLIC ACID

There total 2 articles about 3-(4-BROMO-2-THIENYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

→ 3-(4-bromo-2-thienyl)acrylic acid (144558-44-1)

Guidance literature:

With piperidine; pyridine; for 2h; Reflux;

Reference yield:

4-Bromothiophen-2-aldehyde (18791-75-8) + malonic acid (141-82-2) → 3-(4-bromo-2-thienyl)acrylic acid (144558-44-1)

Guidance literature:

4-Bromothiophen-2-aldehyde; malonic acid; piperidine; In pyridine; for 6h; Heating / reflux;

With hydrogenchloride; In pyridine; water; at 0 ℃;

Reference yield: 47.0%

3-(4-bromo-2-thienyl)acrylic acid (144558-44-1) + 1-phenyl-4-cyclohexanone (4894-75-1) → C18H15BrOS

Guidance literature:

With copper(II) acetate monohydrate; silver carbonate; CyJohnPhos; In 1,2-dichloro-ethane; at 130 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1002/anie.201906264

upstream raw materials:

4-Bromothiophen-2-aldehyde

malonic acid

Refernces

• 1、 -. "Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase". Page/Page column 63. . Retrieved 2008/12/06.