4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

Base Information

Chemical Name:4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide
CAS No.:1610372-33-2
Molecular Formula:C₂₅H₂₃N₃O₄
Molecular Weight:429.475
Hs Code.:

Synonyms:4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

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Chemical Property of 4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

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Technology Process of 4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

There total 5 articles about 4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 400727-57-3
N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1610373-01-7
3-(6-bromopyridin-2-yl)-6,8-dimethoxyisoquinolin-1(2H)-one

: 1610372-33-2
4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 122918-25-6
6-bromopyridin-2-carbonitrile

: 1610372-33-2
4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 - 0 °C

1.2: 24 h / 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 18 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; ethanol; water;

Reference yield:

: 3686-57-5
2,4-dimethoxy-6-methylbenzoic acid

: 1610372-33-2
4-(6-(6,8-dimethoxy-1-oxo-1,2-dihydroisoquinolin-3-yl)pyridin-2-yl)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 - 0 °C

1.2: 24 h / 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 18 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; ethanol; water;